Libros
2005
Torres, N.V. and Voit, E.O. 2005. Pathway Analysis and Optimization in Metabolic Engineering. Chinese Edition. Edited by Chinese Chemical Industry Press. Translated by Prof. Dr. Zhi-Long Xiu Department of Bioscience and Biotechnology. School of Environmental and Biological Science and Technology. DalianUniversity of Technology.
2002
Torres, N.V. and Voit, E.O. 2002. Pathway Analysis and Optimization in Metabolic Engineering. Cambridge University Press.
Torres, N.V. and Voit, E.O. 2005. Pathway Analysis and Optimization in Metabolic Engineering. Chinese Edition. Edited by Chinese Chemical Industry Press. Translated by Prof. Dr. Zhi-Long Xiu Department of Bioscience and Biotechnology. School of Environmental and Biological Science and Technology. DalianUniversity of Technology.
2002
Torres, N.V. and Voit, E.O. 2002. Pathway Analysis and Optimization in Metabolic Engineering. Cambridge University Press.
Capítulos de Libros
2013
J. Vera, N. Torres. 2013. Biochemical Systems Optimization through Mathematical Programming. Encyclopedia of Systems Biology. Encyclopedia os Syst. pp. 1-10. Berlin. AlemaniaSpringer-Verlag. 17/03/2013. http://www.springerreference.com/docs/html/chapterdbid/308959.html
D. Guebel, N. Torres. 2013. Multivariative Methods for System deconstruction. Encyclopedia of Systems Biology. Encyclopedia os Syst. pp. 1-10. Berlin. AlemaniaSpringer-Verlag. 17/03/2013. http://www.springerreference.com/docs/html/chapterdbid/305899.html
2006
J. Vera, J. Bachmann, A. C. Pfeifer, J.A. Hormiga, N.V. Torres Darias, U. Klingmüller, and O. Wolkenhauer. 2006. A power-law model to describe the dynamics of the JAK2-STAT5 signalling pathway. In “Understanding and Exploiting Systems Biology in Biomedicine and Bioprocesses”. Editors: Manuel Cánovas, José L. Iborra And Arturo Manjón. ISBN 84-611-1135-4. D. L. MU-1036-2006.
A. Marín-Sanguino, C. González Alcón, E.O. Voit and N.V. Torres Darias. 2006. Towards a rational approach to metabolic engineering: Indirect Optimization Methods. In “Understanding and Exploiting Systems Biology in Biomedicine and Bioprocesses”. Editors: Manuel Cánovas, José L. Iborra And Arturo Manjón. ISBN 84-611-1135-4. D. L. MU-1036-2006. pag: 59-64
Julio Vera-González, Néstor V. Torres, Raúl Curtoand Marta Cascante. 2006. Identification of enzyme targets in metabolic diseases by modelling and optimisation. The case of hyperuricemia in humans. In “Understanding and Exploiting Systems Biology in Biomedicine and Bioprocesses”. Editors: Manuel Cánovas, José L. Iborra And Arturo Manjón. ISBN 84-611-1135-4. D. L. MU-1036-2006
2004
Torres, N.V., Alvarez-Vasquez, F. and Voit, E.O. 2004. Introduction to the Theory of Metabolic Modeling and Optimization of Biotechnological Processes with S-System Models.Applications to Citric Acid Production in Aspergillus niger. In David Smith: Handbook of Fungal Biotechnology. Second Edition. Revised and Expanded. Marcel Dekker, Inc. New York, U.S.A. ISBN0-8247-4018-1. Chapter 27. pg: 353-366.Vera,
J., González-Alcón, C. M. and Torres, N.V. 2004. Multiobjetive Optimization Of Biochemical Systems. In Recent Research Developments in Applied Microbiology & BiotechnologyVol. 1. 375- 390. ISBN: 81-271-0043-9(S.G. Pandalay Ed.) Research Signpost. Trivandrum. India.
2003
Torres, N.V. 2003. Modelización matemática y optimización de bioprocesos: Métodosy aplicaciones. En “Sociedad, Ciencia, Tecnología y Matemáticas”, Módulo 2. Marrero Rodríguez M.I. y Trujillo, R. Eds. ISBN: 84-932960-4-X (Obra Completa).
1998
Voit, E.O. and Torres, N.V.1998. Canonical Modeling of Complex Pathways in biotechnology. In Recent Research Developments in Biotechnology & Bioengineering. (S.G. Pandalay Ed) Research Signpost. Trivandrum. India. 1: 321-341.
J. Vera, N. Torres. 2013. Biochemical Systems Optimization through Mathematical Programming. Encyclopedia of Systems Biology. Encyclopedia os Syst. pp. 1-10. Berlin. AlemaniaSpringer-Verlag. 17/03/2013. http://www.springerreference.com/docs/html/chapterdbid/308959.html
D. Guebel, N. Torres. 2013. Multivariative Methods for System deconstruction. Encyclopedia of Systems Biology. Encyclopedia os Syst. pp. 1-10. Berlin. AlemaniaSpringer-Verlag. 17/03/2013. http://www.springerreference.com/docs/html/chapterdbid/305899.html
2006
J. Vera, J. Bachmann, A. C. Pfeifer, J.A. Hormiga, N.V. Torres Darias, U. Klingmüller, and O. Wolkenhauer. 2006. A power-law model to describe the dynamics of the JAK2-STAT5 signalling pathway. In “Understanding and Exploiting Systems Biology in Biomedicine and Bioprocesses”. Editors: Manuel Cánovas, José L. Iborra And Arturo Manjón. ISBN 84-611-1135-4. D. L. MU-1036-2006.
A. Marín-Sanguino, C. González Alcón, E.O. Voit and N.V. Torres Darias. 2006. Towards a rational approach to metabolic engineering: Indirect Optimization Methods. In “Understanding and Exploiting Systems Biology in Biomedicine and Bioprocesses”. Editors: Manuel Cánovas, José L. Iborra And Arturo Manjón. ISBN 84-611-1135-4. D. L. MU-1036-2006. pag: 59-64
Julio Vera-González, Néstor V. Torres, Raúl Curtoand Marta Cascante. 2006. Identification of enzyme targets in metabolic diseases by modelling and optimisation. The case of hyperuricemia in humans. In “Understanding and Exploiting Systems Biology in Biomedicine and Bioprocesses”. Editors: Manuel Cánovas, José L. Iborra And Arturo Manjón. ISBN 84-611-1135-4. D. L. MU-1036-2006
2004
Torres, N.V., Alvarez-Vasquez, F. and Voit, E.O. 2004. Introduction to the Theory of Metabolic Modeling and Optimization of Biotechnological Processes with S-System Models.Applications to Citric Acid Production in Aspergillus niger. In David Smith: Handbook of Fungal Biotechnology. Second Edition. Revised and Expanded. Marcel Dekker, Inc. New York, U.S.A. ISBN0-8247-4018-1. Chapter 27. pg: 353-366.Vera,
J., González-Alcón, C. M. and Torres, N.V. 2004. Multiobjetive Optimization Of Biochemical Systems. In Recent Research Developments in Applied Microbiology & BiotechnologyVol. 1. 375- 390. ISBN: 81-271-0043-9(S.G. Pandalay Ed.) Research Signpost. Trivandrum. India.
2003
Torres, N.V. 2003. Modelización matemática y optimización de bioprocesos: Métodosy aplicaciones. En “Sociedad, Ciencia, Tecnología y Matemáticas”, Módulo 2. Marrero Rodríguez M.I. y Trujillo, R. Eds. ISBN: 84-932960-4-X (Obra Completa).
1998
Voit, E.O. and Torres, N.V.1998. Canonical Modeling of Complex Pathways in biotechnology. In Recent Research Developments in Biotechnology & Bioengineering. (S.G. Pandalay Ed) Research Signpost. Trivandrum. India. 1: 321-341.
Artículos
2016
Guido Santos; Mario Díaz; Nestor V. Torres. Lipid Raft Size and Lipid Mobility in Non-raft Domains Increase during Aging and Are Exacerbated in APP/PS1 Mice Model of Alzheimer's Disease. Predictions from an Agent-Based Mathematical Model. Frontiers in Physiology. 7:90, 01/03/2016.
2015
Nestor Torres; Guido Santos. The (mathematical) modelling process in biosciences, by Nestor V. Torres, Guido Santos, published in Frontiers in Genetics, section Systems Biology. Frontiers in Genetics. 6 - 354, Frontiers, 22/12/2015.
Daniel Guebel; Montserrat Perera-Alberto; Nestor Torres Darias. Q-GDEMAR: a general method for the identification of differentially expressed genes in microarrays with unbalanced groups. Molecular Biosystems. DOI: 10.1039/C5MB005, Royal Society of Chemistry, 30/10/2015.
2014
Néstor Torres Darias; Carlos González Alcón; José Hormiga. Development and Application of a Modified Genetic Algorithm for Estimating Parameters in GMA Models. Applied Mathematics. 5, pp. 2447 - 2457. Scietific Research, 15/09/2014.
Guido Santos; Nestor Torres. Intra-host mathematical models of malaria. CAB Reviews. 9 - 25, pp. 1 - 7. CABI Publishers, 05/09/2014.
Guido Santos; Agustín Valenzuela Fernández; Néstor Torres. Quantitative Analysis of the Processes and Signaling Events Involved in Early HIV-1 Infection of T Cells. PLoS ONE. 9 - 8, pp. 1 - 17. PLoS, 08/08/2014. Tipo de producción:
2013
Néstor Torres. Introducing systems biology to bioscience students through mathematical modelling. a practical module. Bioscience Education. 21 - doi:10.11120/beej.20, pp. 1 - 10. The Higher Education Academy, 28/08/2013.
Velasco-Bedrán Hugo; Jose Hormiga; Guido Santos Rosales; Nestor Torres Darias. Model-based analysis of a phenol bio-oxidation process by adhered and suspended Candida tropicalis. Applied Mathematics. doi:10.4236/am.2013, pp. 1 - 9. Scientific Research, 15/08/2013.
Guido Santos, Néstor V. Torres. New targets for drug discovery against malaria. doi: 10.1371/journal.pone.0059968, PLoS one. Vol 8(3):e59968
2012
Bettina Länger, Cristina Pou-Barreto, Carlos González-Alcón, Basilio Valladares, Bettina Wimmer, Néstor V. Torres. Modeling of leishmaniasis infection dynamics: novel application to the design of effective therapies. doi: 10.1186/1752-0509-6-1, BMC Systems Biology. Vol 5(6):1
Guido Santos, José A. Hormiga, Paula Arense, Manuel Cánovas, Néstor V. Torres. Modelling and analysis of central metabolism operating regulatory interactions in salt stress conditions in a L-carnitine overproducing E. coli strain. doi: 10.1371/journal.pone.0034533, PLoS one. Vol 7(4):e34533
2011
Néstor V. Torres. ¿Qué es la Biología de Sistemas? Encuentros en la Biología. 4-136, pp. 59-60. UMA.05/12/2011
Jacqueline García, Néstor V. Torres. Mathematical modelling and assessment of the homeostasis mechanisms in Aspergillus niger while in citric acid producing conditions. J. Theor. Biol. 282(1). pp. 23-35. 2011
2010
José A. Hormiga, Carlos González-Alcón, Angel Sevilla, Manuel Cánovas, Néstor V. Torres. A system biology approach to analysing of the dynamic signaling pathway involved in the AMP mediated induction of L-carnitine byosynthesis in E. coli cultures. doi: 10.1039/b913063b, Molecular Biosystems. Vol 6(4) 699-710
Hormiga, José A.; Almansa, Eduardo; Sykes, Antonio V.; Torres, Néstor V., Model based optimization of feeding regimens in aquaculture: application to the improvement of octopus vulgaris viability in captivity DOI: 10.1016/j.jbiotec.2010.12.008, Journal of Biotechnology
Vera, Julio; González-Alcón, Carlos; Marín-Sanguino, Alberto; Torres, Néstor.Optimization of biochemical systems through mathematical programming: methods and applications. Computer and Operations Research, Vol 37(8), 1427-1438
2009
Guebel, Daniel V.; Cánovas, Manuel; Torres, Néstor V. Torres,Analysis of the escherichia coli response to glycerol pulse in continuous, high cell density culture using a multivariate approach, Biotechnology and Bioengineering, Vol 102(3) 910-922
A. Marín-Sanguino, Néstor V. Torres, E. R. Mendoza, D. Oesterhelt, Metabolic Engineering with Power-law and linear-logarithmic Systems, Mathematical Biosciences, Vol 218(1) 50-58
Daniel V. Guebel, Manuel Cánovas, Néstor V. Torres, Model identification in presence of incomplete information by Generalized Principal Component Analysis. Application to the common and differential responses of Escherichia coli to multiple pulse perturbations in continuous, high-biomass density culture, Biotechnology and Bioengineering. 104(4),pp. 785-795. 2009
Daniel V. Guebel, Manuel Cánovas and Néstor V. Torres, Analysis of the Escherichia coli response to glycerol pulse in continuous, high cell density culture using a multivariate approach, Biotechnology and Bioengineering, Vol 102(3), pp 910-22. 2009
2008
J. Vera, J. Bachmann, A.C. Pfeifer, V. Becker, J.A. Hormiga, N.V. Torres Darias, J. Timmer, U. Klingmüller and O. Wolkenhauer. 2008.A systems biology approach to analyse amplification in the JAK2-STAT5 signalling pathway. BMC Systems Biology. 2:38, pp. Doi 10.1186/1752-0509-2-38. 2008
Daniel V. Guebel, Néstor V. Torres. 2008. Integrated mathematical model of the oxygen gradient pattern distribution in the human colon mucosa. Implications in cancer development. Journal Theoretical Biology. 250: 389-409. ISSN: 0022-5193.
J.A. Hormiga, J. Vera, I. Frías and N.V. Torres DariasTítulo: Growth and ligninolytic system production dynamics of the Phanerochaete chrysosporium fungus. A modelling and optimization approach., Journal of Biotechnology, Vol: 137, 50-58
Hannes, Link; Vera, Julio;Weuster-Botz, Dirk; Torres Darias, Néstor and Franco-Lara, Ezequiel. Multi-objective steady-state optimization of biochemical reaction networks using a constrained genetic algorithm. Computer and Chemical Engineering. 2008.
2007
Julio Vera, Marta Cascante, Raul Curto and Néstor V. Torres, 2007. Identification Of Enzymatic Targets In Metabolic Diseases By Modelling and Optimisation. The Case Of Hyperuricemia In Humans. Bioinformatics. 23(17): 2281-2289. ISSN: 1367-4803.
Marin-Sanguino, A.,Voit, E.O., Gonzalez-Alcon, C. and Torres, N.V. 2007. Optimization of Biotechnological Systems through Geometric Programming. BCM Theoretical Biology and Medical Modelling. 4:38. Sep 26, 2007. http://www.tbiomed.com/content/4/1/38.doi:10.1186/1742-4682-4-38.
2006
Daniel V. Guebel, Néstor V. Torres and M. Cánovas. 2006. Modeling analysis of the L(-)-carnitine production process by Escherichia coli. Process Biochemistry. 41(2) 281-288. DOI: 10.1016/j.procbio.2005.08.013. ISSN: 1359-5113.
O. Sendín, J. Vera, N. Torres and J. Banga. 2006. Model based optimization of biochemical systems using multiple objectives: a comparison of two solution strategies. Mathematical and Computer Modelling of Dynamical Systems. 12 (5): 469-487. ISSN: 1387-3954.
2005
Sevilla, A., Vera, J., Díaz, Z., Cánovas, M., Torres, N.V. e Iborra, J.L. 2005. Design of metabolic engineering strategies for maximizing L(-)-carnitine production by Escherichia coli. Integration of the metabolic and bioreactor levels. Biotechnol. Progress. 21, 329-337. ISSN: 8756-7938.
Torres, N.V. and Voit, E.O. 2005. Pathway Analysis and Optimization in Metabolic Engineering. Chinese Edition. Edited by Chinese Chemical Industry Press. Translated by Prof. Dr. Zhi-Long Xiu Department of Bioscience and Biotechnology. School of Environmental and Biological Science and Technology. DalianUniversity of Technology.
2004
Julio Vera and Néstor V. Torres. 2004. MetTMAP: An integrated Matlab© package for analysis and optimisation of metabolic systems. 2003. In silico Biology. 4: 1-13:http://www.bioinfo.de/isb/2003/04/0010/. ISSN: 1386-6338
Julio Vera, Carmen G. Moles, Julio Banga and Néstor V. Torres. 2004.Optimal non-linear design and control of bioprocesses bylinear programming. Application To A Wastewater Treatment Plant. Proceedings of the 9th International Symposium of Computer Applications in Biotechnology.
Julio Vera and Néstor V. Torres. 2004. Analysis and optimisation of bioprocesses with MetTMAP. Proceedings of the 9th International Symposium of Computer Applications in Biotechnology.
M. Cánovas, A. Sevilla, V. Bernal, N.V. Torres and J.L. Iborra. 2004. Integrating the microkinetics of the L-carnitine and central metabolism in Escherichia coli with the macrokinetics of a high-cell density reactor. Proceedings of the 9th International Symposium of Computer Applications in Biotechnology.
Daniel V. Guebel and Néstor V. Torres. 2004. Dynamic of sulphur amino acids in mammalian brain: assesment of the astrocytic-neuronal cysteine interaction by a mathematical model. Biochem. Biophys. Acta. General Subjects. 1674: 12-21. ISSN: 0304-4165
Cánovas, M., Sevilla, A., Bernal, V. Torres, N. e Iborra, J.L. 2004. Integrating the makrokinetics of the L-carnitine and central metabolism in Escherichia coli with the macrokinetics of a high-cell density reactor. CAB9 84. Elsevier. Ltd.pg. 425-434.
Torres, N.V., Alvarez-Vasquez, F. and Voit, E.O. 2004. Introduction to the Theory of Metabolic Modeling and Optimization of Biotechnological Processes with S-System Models.Applications to Citric Acid Production in Aspergillus niger. In David Smith: Handbook of Fungal Biotechnology. Second Edition. Revised and Expanded. Marcel Dekker, Inc. New York, U.S.A. ISBN0-8247-4018-1. Chapter 27. pg: 353-366.
Vera, J., González-Alcón, C. M. and Torres, N.V. 2004. Multiobjetive Optimization Of Biochemical Systems. In Recent Research Developments in Applied Microbiology & BiotechnologyVol. 1. 375- 390. ISBN: 81-271-0043-9(S.G. Pandalay Ed.) Research Signpost. Trivandrum. India.
2003
Vera, J., De Atauri, P., Cascante, M. and Torres, N.V. 2003. Multicriteria optimization of biochemical systems by linear programming. Application to the ethanol production bySaccharomyces cerevisiae. Biotechnology and Bioengineering. 83 (3) 335-343. ISSN: 0006-3592.
Alberto Marín-Sanguino and Néstor V. Torres. 2003. Optimization of Biochemical Systems by Linear Programming And General Mass Action Model Representations. Mathematical Biosciences. 184(2): 187-200.
Julio Vera, Carmen G. Moles, Julio Banga and Néstor V. Torres. 2003.Simultaneous Design And Control Non-Linear Optimization Through Linear Programming. Application To A Wastewater Treatment Plant. AIChe Journal. 49(12): 3173-3187.
2002
Peksel,A.,Torres, N.V., Liu, J-L, Juneau, G. andKubicek, C.P. 2002. 13C-NMR analysis of glucose metabolism during citric acid production by Aspergillusniger. Appl. Microbiol. Biotechnol. 58, 157-163.
Marín-Sanguino A. and Torres, N.V. 2002. Modelling, steady state analysis and optimization of the catalytic efficiency of the triosephosphate. Bull. Mathem. Biol. 64 (2): 301-326. ISSN: 0092-8240.
Alvarez-Vasquez, F., Cánovas, M., Iborra, J.L. and Torres, N.V. 2002. Modelling and optimization of continuous L-(-)-carnitine production by high-density Escherichia coli cultures. Biotechnology and Bioengineering. 80(7): 794-805. ISSN: 0006-3592.
Torres, N.V. and Voit, E.O. 2002. Pathway Analysis and Optimization in Metabolic Engineering. CambridgeUniversity Press. ISBN: 0521800382.
2001
Guebel, D.V., Torres Darias, N.V. 2001. Optimization of the citric acid production by A. nigerthrough a metabolic flux balance model. EJB: Electronic Journal of Biotechnology [on line], disponible en:http://www.ejbiotechnology.info/content/vol4/issue1/full/2/. ISSN: 0717-3458).
2000
Marín-Sanguino, A. and Torres, N.V. 2000. Optimization of tryptophan production in bacteria. Design of a strategy for genetic manipulation of the tryptophan operon for tryptophan flux maximization. Biotechnology Progress. 16(2): 133-145. ISSN: 8756-7938.
Alvarez-Vasquez, F., González-Alcón, C.M. and Torres, N.V. 2000. Metabolism of citric acid production by Aspergillus niger. Model definition, steady state analysis, dynamic behavior and constrained optimization of citric acid production rate. Biotechnology and Bioengineering. 70(1): 82-108. ISSN: 0006-3592.
1999
Rodríguez-Acosta, F., Regalado, C.M. and Torres, N.V. 1999. Non-linear optimization of biotechnological processes by stochastic algorithms: Application to the maximization of the rate production of ethanol, glycerol and carbohydrate production by Saccharomyces cerevisiae. J. Biotechnol. 68: 15-28. ISSN: 0168-1656.
1998
N. V. Torres, Eberhard O. Voit, Carlos González-Alcón and Felipe Rodríguez. 1998. A Novel Approach to Design of Overexpression Strategy for Metabolic Engineering. Application to the Carbohydrate Metabolism in the Citric Acid Producing Mould Aspergillus niger. Food Technology and Biotechnology.36(3): 177-184. ISSN: 1330-9862.
1997
Torres, N.V., Voit, E.O. González-Alcón, C. and Rodríguez, F.,1997. An Indirect Optimization Method for Biochemical Systems: Description of the Method and Application to Ethanol, Glycerol and Carbohydrates Production in Saccharomyces cerevisiae. Biotechnol. Bioeng. 55(5). 758-772. ISSN: 0006-3592.
Netik, A., Torres, N.V., Riol-Cimas, J.M. and Kubicek, C.P. 1997. Uptake and secretion of citric acid by Aspergillus niger is reciprocally regulated by manganese ions. Biochemical and Biophysical Acta. Biomembranes. 1326(2), 287-294. ISSN 0005-2736.
1996
Torres, N.V., Voit, E.O. and González-Alcón, C. 1996. Optimization of Nonlinear Biotechnological processes With Linear Programming. Application to citric Acid Production by Aspergillus niger. Biotechnol. Bioeng. 49: 247-258. ISSN: 0006-3592.
Torres, N.V., Riol-Cimas, J.M., Wolschek, M. and Kubicek, C.P. 1996. Glucose Transport byAspergillus niger: the low affinity carrier is only formed during growth on high glucose concentrations. Appl. Microb. Biotechnol. 44: 790-794. ISSN: 0175-7598.
Torres, N.V. 1996. S-system modeling approach to ecosystems: Application to a study of the magnesium flow in a tropical forest. Ecol. Model. 89: 109-120. ISSN 0304-3800.
Lupiañez, J.A., García-Salguero, L., Torres, N.V., Peragón, J. and Meléndez-Hevia, E. 1996. Metabolic Support of the flight Promptness of Birds. Comparative Biochemistry and Physiology B. Biochemistry & Molecular Biology 113B: 439-443. ISSN: 0305-0491.
Torres, N.V. 1996. Metabolic Control Analysis of the Inhibitory Feedback Interaction: Application to Biotechnological Processes. J. Theor. Biol. 182: 405-410. ISSN: 0022-5193.
1995
Voit, E. O, Torres, N. V. 1995. Simulation and steady-state optimization of integrated biochemical systems: Theory and applications in biotechnology. Conference Information: 1995 EUROSIM Conference (EUROSIM 95). Date: SEP 11-15, 1995. Vienna. Austria. Source: Eurosim '95 Simulation Congress. Pages: 939-944. Published: 1995.
1994
Torres, N.V. 1994. Modeling approach to control of carbohydrate metabolism during citric acid accumulation by Aspergillus niger. I. Model definition and stability of the steady state. Biotechnol. Bioeng. 44: 104-111. ISSN: 0006-3592.
Torres, N.V. 1994. Modeling approach to control of carbohydrate metabolism during citric acid accumulation by Aspergillus niger. II. Sensitivity analysis. Biotechnol. Bioeng. 44: 112-118. ISSN: 0006-3592.
Torres, N.V. 1994. Application of the Transition Time of metabolic systems as a criterion for optimization of metabolic processes. Biotechnol. Bioeng. 44: 291-296. ISSN: 0006-3592.
Guido Santos; Mario Díaz; Nestor V. Torres. Lipid Raft Size and Lipid Mobility in Non-raft Domains Increase during Aging and Are Exacerbated in APP/PS1 Mice Model of Alzheimer's Disease. Predictions from an Agent-Based Mathematical Model. Frontiers in Physiology. 7:90, 01/03/2016.
2015
Nestor Torres; Guido Santos. The (mathematical) modelling process in biosciences, by Nestor V. Torres, Guido Santos, published in Frontiers in Genetics, section Systems Biology. Frontiers in Genetics. 6 - 354, Frontiers, 22/12/2015.
Daniel Guebel; Montserrat Perera-Alberto; Nestor Torres Darias. Q-GDEMAR: a general method for the identification of differentially expressed genes in microarrays with unbalanced groups. Molecular Biosystems. DOI: 10.1039/C5MB005, Royal Society of Chemistry, 30/10/2015.
2014
Néstor Torres Darias; Carlos González Alcón; José Hormiga. Development and Application of a Modified Genetic Algorithm for Estimating Parameters in GMA Models. Applied Mathematics. 5, pp. 2447 - 2457. Scietific Research, 15/09/2014.
Guido Santos; Nestor Torres. Intra-host mathematical models of malaria. CAB Reviews. 9 - 25, pp. 1 - 7. CABI Publishers, 05/09/2014.
Guido Santos; Agustín Valenzuela Fernández; Néstor Torres. Quantitative Analysis of the Processes and Signaling Events Involved in Early HIV-1 Infection of T Cells. PLoS ONE. 9 - 8, pp. 1 - 17. PLoS, 08/08/2014. Tipo de producción:
2013
Néstor Torres. Introducing systems biology to bioscience students through mathematical modelling. a practical module. Bioscience Education. 21 - doi:10.11120/beej.20, pp. 1 - 10. The Higher Education Academy, 28/08/2013.
Velasco-Bedrán Hugo; Jose Hormiga; Guido Santos Rosales; Nestor Torres Darias. Model-based analysis of a phenol bio-oxidation process by adhered and suspended Candida tropicalis. Applied Mathematics. doi:10.4236/am.2013, pp. 1 - 9. Scientific Research, 15/08/2013.
Guido Santos, Néstor V. Torres. New targets for drug discovery against malaria. doi: 10.1371/journal.pone.0059968, PLoS one. Vol 8(3):e59968
2012
Bettina Länger, Cristina Pou-Barreto, Carlos González-Alcón, Basilio Valladares, Bettina Wimmer, Néstor V. Torres. Modeling of leishmaniasis infection dynamics: novel application to the design of effective therapies. doi: 10.1186/1752-0509-6-1, BMC Systems Biology. Vol 5(6):1
Guido Santos, José A. Hormiga, Paula Arense, Manuel Cánovas, Néstor V. Torres. Modelling and analysis of central metabolism operating regulatory interactions in salt stress conditions in a L-carnitine overproducing E. coli strain. doi: 10.1371/journal.pone.0034533, PLoS one. Vol 7(4):e34533
2011
Néstor V. Torres. ¿Qué es la Biología de Sistemas? Encuentros en la Biología. 4-136, pp. 59-60. UMA.05/12/2011
Jacqueline García, Néstor V. Torres. Mathematical modelling and assessment of the homeostasis mechanisms in Aspergillus niger while in citric acid producing conditions. J. Theor. Biol. 282(1). pp. 23-35. 2011
2010
José A. Hormiga, Carlos González-Alcón, Angel Sevilla, Manuel Cánovas, Néstor V. Torres. A system biology approach to analysing of the dynamic signaling pathway involved in the AMP mediated induction of L-carnitine byosynthesis in E. coli cultures. doi: 10.1039/b913063b, Molecular Biosystems. Vol 6(4) 699-710
Hormiga, José A.; Almansa, Eduardo; Sykes, Antonio V.; Torres, Néstor V., Model based optimization of feeding regimens in aquaculture: application to the improvement of octopus vulgaris viability in captivity DOI: 10.1016/j.jbiotec.2010.12.008, Journal of Biotechnology
Vera, Julio; González-Alcón, Carlos; Marín-Sanguino, Alberto; Torres, Néstor.Optimization of biochemical systems through mathematical programming: methods and applications. Computer and Operations Research, Vol 37(8), 1427-1438
2009
Guebel, Daniel V.; Cánovas, Manuel; Torres, Néstor V. Torres,Analysis of the escherichia coli response to glycerol pulse in continuous, high cell density culture using a multivariate approach, Biotechnology and Bioengineering, Vol 102(3) 910-922
A. Marín-Sanguino, Néstor V. Torres, E. R. Mendoza, D. Oesterhelt, Metabolic Engineering with Power-law and linear-logarithmic Systems, Mathematical Biosciences, Vol 218(1) 50-58
Daniel V. Guebel, Manuel Cánovas, Néstor V. Torres, Model identification in presence of incomplete information by Generalized Principal Component Analysis. Application to the common and differential responses of Escherichia coli to multiple pulse perturbations in continuous, high-biomass density culture, Biotechnology and Bioengineering. 104(4),pp. 785-795. 2009
Daniel V. Guebel, Manuel Cánovas and Néstor V. Torres, Analysis of the Escherichia coli response to glycerol pulse in continuous, high cell density culture using a multivariate approach, Biotechnology and Bioengineering, Vol 102(3), pp 910-22. 2009
2008
J. Vera, J. Bachmann, A.C. Pfeifer, V. Becker, J.A. Hormiga, N.V. Torres Darias, J. Timmer, U. Klingmüller and O. Wolkenhauer. 2008.A systems biology approach to analyse amplification in the JAK2-STAT5 signalling pathway. BMC Systems Biology. 2:38, pp. Doi 10.1186/1752-0509-2-38. 2008
Daniel V. Guebel, Néstor V. Torres. 2008. Integrated mathematical model of the oxygen gradient pattern distribution in the human colon mucosa. Implications in cancer development. Journal Theoretical Biology. 250: 389-409. ISSN: 0022-5193.
J.A. Hormiga, J. Vera, I. Frías and N.V. Torres DariasTítulo: Growth and ligninolytic system production dynamics of the Phanerochaete chrysosporium fungus. A modelling and optimization approach., Journal of Biotechnology, Vol: 137, 50-58
Hannes, Link; Vera, Julio;Weuster-Botz, Dirk; Torres Darias, Néstor and Franco-Lara, Ezequiel. Multi-objective steady-state optimization of biochemical reaction networks using a constrained genetic algorithm. Computer and Chemical Engineering. 2008.
2007
Julio Vera, Marta Cascante, Raul Curto and Néstor V. Torres, 2007. Identification Of Enzymatic Targets In Metabolic Diseases By Modelling and Optimisation. The Case Of Hyperuricemia In Humans. Bioinformatics. 23(17): 2281-2289. ISSN: 1367-4803.
Marin-Sanguino, A.,Voit, E.O., Gonzalez-Alcon, C. and Torres, N.V. 2007. Optimization of Biotechnological Systems through Geometric Programming. BCM Theoretical Biology and Medical Modelling. 4:38. Sep 26, 2007. http://www.tbiomed.com/content/4/1/38.doi:10.1186/1742-4682-4-38.
2006
Daniel V. Guebel, Néstor V. Torres and M. Cánovas. 2006. Modeling analysis of the L(-)-carnitine production process by Escherichia coli. Process Biochemistry. 41(2) 281-288. DOI: 10.1016/j.procbio.2005.08.013. ISSN: 1359-5113.
O. Sendín, J. Vera, N. Torres and J. Banga. 2006. Model based optimization of biochemical systems using multiple objectives: a comparison of two solution strategies. Mathematical and Computer Modelling of Dynamical Systems. 12 (5): 469-487. ISSN: 1387-3954.
2005
Sevilla, A., Vera, J., Díaz, Z., Cánovas, M., Torres, N.V. e Iborra, J.L. 2005. Design of metabolic engineering strategies for maximizing L(-)-carnitine production by Escherichia coli. Integration of the metabolic and bioreactor levels. Biotechnol. Progress. 21, 329-337. ISSN: 8756-7938.
Torres, N.V. and Voit, E.O. 2005. Pathway Analysis and Optimization in Metabolic Engineering. Chinese Edition. Edited by Chinese Chemical Industry Press. Translated by Prof. Dr. Zhi-Long Xiu Department of Bioscience and Biotechnology. School of Environmental and Biological Science and Technology. DalianUniversity of Technology.
2004
Julio Vera and Néstor V. Torres. 2004. MetTMAP: An integrated Matlab© package for analysis and optimisation of metabolic systems. 2003. In silico Biology. 4: 1-13:http://www.bioinfo.de/isb/2003/04/0010/. ISSN: 1386-6338
Julio Vera, Carmen G. Moles, Julio Banga and Néstor V. Torres. 2004.Optimal non-linear design and control of bioprocesses bylinear programming. Application To A Wastewater Treatment Plant. Proceedings of the 9th International Symposium of Computer Applications in Biotechnology.
Julio Vera and Néstor V. Torres. 2004. Analysis and optimisation of bioprocesses with MetTMAP. Proceedings of the 9th International Symposium of Computer Applications in Biotechnology.
M. Cánovas, A. Sevilla, V. Bernal, N.V. Torres and J.L. Iborra. 2004. Integrating the microkinetics of the L-carnitine and central metabolism in Escherichia coli with the macrokinetics of a high-cell density reactor. Proceedings of the 9th International Symposium of Computer Applications in Biotechnology.
Daniel V. Guebel and Néstor V. Torres. 2004. Dynamic of sulphur amino acids in mammalian brain: assesment of the astrocytic-neuronal cysteine interaction by a mathematical model. Biochem. Biophys. Acta. General Subjects. 1674: 12-21. ISSN: 0304-4165
Cánovas, M., Sevilla, A., Bernal, V. Torres, N. e Iborra, J.L. 2004. Integrating the makrokinetics of the L-carnitine and central metabolism in Escherichia coli with the macrokinetics of a high-cell density reactor. CAB9 84. Elsevier. Ltd.pg. 425-434.
Torres, N.V., Alvarez-Vasquez, F. and Voit, E.O. 2004. Introduction to the Theory of Metabolic Modeling and Optimization of Biotechnological Processes with S-System Models.Applications to Citric Acid Production in Aspergillus niger. In David Smith: Handbook of Fungal Biotechnology. Second Edition. Revised and Expanded. Marcel Dekker, Inc. New York, U.S.A. ISBN0-8247-4018-1. Chapter 27. pg: 353-366.
Vera, J., González-Alcón, C. M. and Torres, N.V. 2004. Multiobjetive Optimization Of Biochemical Systems. In Recent Research Developments in Applied Microbiology & BiotechnologyVol. 1. 375- 390. ISBN: 81-271-0043-9(S.G. Pandalay Ed.) Research Signpost. Trivandrum. India.
2003
Vera, J., De Atauri, P., Cascante, M. and Torres, N.V. 2003. Multicriteria optimization of biochemical systems by linear programming. Application to the ethanol production bySaccharomyces cerevisiae. Biotechnology and Bioengineering. 83 (3) 335-343. ISSN: 0006-3592.
Alberto Marín-Sanguino and Néstor V. Torres. 2003. Optimization of Biochemical Systems by Linear Programming And General Mass Action Model Representations. Mathematical Biosciences. 184(2): 187-200.
Julio Vera, Carmen G. Moles, Julio Banga and Néstor V. Torres. 2003.Simultaneous Design And Control Non-Linear Optimization Through Linear Programming. Application To A Wastewater Treatment Plant. AIChe Journal. 49(12): 3173-3187.
2002
Peksel,A.,Torres, N.V., Liu, J-L, Juneau, G. andKubicek, C.P. 2002. 13C-NMR analysis of glucose metabolism during citric acid production by Aspergillusniger. Appl. Microbiol. Biotechnol. 58, 157-163.
Marín-Sanguino A. and Torres, N.V. 2002. Modelling, steady state analysis and optimization of the catalytic efficiency of the triosephosphate. Bull. Mathem. Biol. 64 (2): 301-326. ISSN: 0092-8240.
Alvarez-Vasquez, F., Cánovas, M., Iborra, J.L. and Torres, N.V. 2002. Modelling and optimization of continuous L-(-)-carnitine production by high-density Escherichia coli cultures. Biotechnology and Bioengineering. 80(7): 794-805. ISSN: 0006-3592.
Torres, N.V. and Voit, E.O. 2002. Pathway Analysis and Optimization in Metabolic Engineering. CambridgeUniversity Press. ISBN: 0521800382.
2001
Guebel, D.V., Torres Darias, N.V. 2001. Optimization of the citric acid production by A. nigerthrough a metabolic flux balance model. EJB: Electronic Journal of Biotechnology [on line], disponible en:http://www.ejbiotechnology.info/content/vol4/issue1/full/2/. ISSN: 0717-3458).
2000
Marín-Sanguino, A. and Torres, N.V. 2000. Optimization of tryptophan production in bacteria. Design of a strategy for genetic manipulation of the tryptophan operon for tryptophan flux maximization. Biotechnology Progress. 16(2): 133-145. ISSN: 8756-7938.
Alvarez-Vasquez, F., González-Alcón, C.M. and Torres, N.V. 2000. Metabolism of citric acid production by Aspergillus niger. Model definition, steady state analysis, dynamic behavior and constrained optimization of citric acid production rate. Biotechnology and Bioengineering. 70(1): 82-108. ISSN: 0006-3592.
1999
Rodríguez-Acosta, F., Regalado, C.M. and Torres, N.V. 1999. Non-linear optimization of biotechnological processes by stochastic algorithms: Application to the maximization of the rate production of ethanol, glycerol and carbohydrate production by Saccharomyces cerevisiae. J. Biotechnol. 68: 15-28. ISSN: 0168-1656.
1998
N. V. Torres, Eberhard O. Voit, Carlos González-Alcón and Felipe Rodríguez. 1998. A Novel Approach to Design of Overexpression Strategy for Metabolic Engineering. Application to the Carbohydrate Metabolism in the Citric Acid Producing Mould Aspergillus niger. Food Technology and Biotechnology.36(3): 177-184. ISSN: 1330-9862.
1997
Torres, N.V., Voit, E.O. González-Alcón, C. and Rodríguez, F.,1997. An Indirect Optimization Method for Biochemical Systems: Description of the Method and Application to Ethanol, Glycerol and Carbohydrates Production in Saccharomyces cerevisiae. Biotechnol. Bioeng. 55(5). 758-772. ISSN: 0006-3592.
Netik, A., Torres, N.V., Riol-Cimas, J.M. and Kubicek, C.P. 1997. Uptake and secretion of citric acid by Aspergillus niger is reciprocally regulated by manganese ions. Biochemical and Biophysical Acta. Biomembranes. 1326(2), 287-294. ISSN 0005-2736.
1996
Torres, N.V., Voit, E.O. and González-Alcón, C. 1996. Optimization of Nonlinear Biotechnological processes With Linear Programming. Application to citric Acid Production by Aspergillus niger. Biotechnol. Bioeng. 49: 247-258. ISSN: 0006-3592.
Torres, N.V., Riol-Cimas, J.M., Wolschek, M. and Kubicek, C.P. 1996. Glucose Transport byAspergillus niger: the low affinity carrier is only formed during growth on high glucose concentrations. Appl. Microb. Biotechnol. 44: 790-794. ISSN: 0175-7598.
Torres, N.V. 1996. S-system modeling approach to ecosystems: Application to a study of the magnesium flow in a tropical forest. Ecol. Model. 89: 109-120. ISSN 0304-3800.
Lupiañez, J.A., García-Salguero, L., Torres, N.V., Peragón, J. and Meléndez-Hevia, E. 1996. Metabolic Support of the flight Promptness of Birds. Comparative Biochemistry and Physiology B. Biochemistry & Molecular Biology 113B: 439-443. ISSN: 0305-0491.
Torres, N.V. 1996. Metabolic Control Analysis of the Inhibitory Feedback Interaction: Application to Biotechnological Processes. J. Theor. Biol. 182: 405-410. ISSN: 0022-5193.
1995
Voit, E. O, Torres, N. V. 1995. Simulation and steady-state optimization of integrated biochemical systems: Theory and applications in biotechnology. Conference Information: 1995 EUROSIM Conference (EUROSIM 95). Date: SEP 11-15, 1995. Vienna. Austria. Source: Eurosim '95 Simulation Congress. Pages: 939-944. Published: 1995.
1994
Torres, N.V. 1994. Modeling approach to control of carbohydrate metabolism during citric acid accumulation by Aspergillus niger. I. Model definition and stability of the steady state. Biotechnol. Bioeng. 44: 104-111. ISSN: 0006-3592.
Torres, N.V. 1994. Modeling approach to control of carbohydrate metabolism during citric acid accumulation by Aspergillus niger. II. Sensitivity analysis. Biotechnol. Bioeng. 44: 112-118. ISSN: 0006-3592.
Torres, N.V. 1994. Application of the Transition Time of metabolic systems as a criterion for optimization of metabolic processes. Biotechnol. Bioeng. 44: 291-296. ISSN: 0006-3592.